Inhibitors of Plasmodium Falciparum Phosphoethanolamine

Question: Talk about the Inhibitors of Plasmodium Falciparum Phosphoethanolamine. Answer: Presentation: 4-aminoquinoline sedate, used to treat jungle fever contamination (Plasmodium ovale, P. vivax and P. malariae) (Na-Bangchang and Karbwang, 2009; Petersen, Eastman and Lanzer, 2011). Intestinal sickness parasite is available in its abiogenetic stage in the red blood corpuscles (RBC) where it breaks hemoglobin, along these lines discharging heme, which is changed over to hemozoin. Chloroquine enters RBC and gets protonated and forestalls hemozoin arrangement, in this manner causing development of heme protein. At that point, chloroquine joins to heme to shape a harmful complex which upsets the film work, in this manner prompting cell-lysis and in the long run autodigestion of the parasite (Hempelmann, 2007; Lin et al., 2015). Its unfavorable impacts incorporate hunger trouble, looseness of the bowels, low RBC, strong harm, vision issues, seizures, skin rash and so on. (Michaelides et al., 2011; Murambiwa et al., 2011; Reich, Stnder and Szepietowski, 2009; Tnnesmann, Kandolf and Lewalte r, 2013). The principal occurrence of chloroquine-obstruction falciparum was accounted for in 1950s; from that point forward, different safe structures have surfaced. Falciparum proficiently check the impacts of chloroquine because of transformations in transporter (PfCRT) quality (Martin et al., 2009). Different qualities associated with advancement of medication opposition are ABC transporter multidrug-obstruction (PfMDR1) and chloroquine-transporter CG2 protein (Tripathi, 2013). Chloroquine has been the medication of decision for unverified instances of intestinal sickness or vivax disease. However, odds of creating drug-opposition are higher because of inappropriate medication use. Along these lines, one must consider the odds of increment of chloroquine-safe vivax contamination in Pakistan (Price et al., 2014). The presence of the F1076L transformation in pvmdr1 quality in Pakistan, liable for tranquilize obstruction in vivax in 2013 causes to notice the approaching danger of o pposition advancement (Khattak et al., 2013; Waheed et al., 2015). Amodiaquine - It is another medication of 4-aminoquinoline class, utilized against straightforward reports of falciparum intestinal sickness. It is energetically prescribed in mix with artesunate to diminish the danger of medication opposition (Bobenchik et al., 2010; WHO, 2015), yet is generally not endorsed because of its uncommon yet serious unfriendly impacts. Some antagonistic impacts remember decline for platelet or hepatic pain and at high portions, it might cause heart failure, cerebral pains, seizures, and upset vision (Nair et al., 2012; Olliaro and Mussano, 2016; Tagbor, Chandramohan, and Greenwood, 2007). It has become a central medication utilized alongside artensunate in straightforward instance of falciparum contamination and is a much of the time picked option in contrast to chloroquine, because of its moderateness and adequacy against chloroquine-safe species in Pakistan. It is widely favored for the administration of vivax and falciparum contamination. However, ther e were reports of cross-opposition among chloroquine and amodiaquine in the South Asian area (Hay et al., 2009). Sulfadoxine + Pyrimethamine - The blend of sulfadoxine (sulfonamide) and pyrimethamine (antiprotozoal) is utilized against intestinal sickness disease (WHO, 2008) in mix with other antimalarial drugs. Sulfonamide acts by contending with the p-amino benzoic corrosive during folate union while the pyrimethamine specifically restrains the dihydrofolate reductase protein present in protozoa, in this manner halting the creation of tetrahydrofolate. Consolidated treatment of the two medications was affirmed in 1981 for use in USA and is currently present on the List of Essential Medicines discharged by the (WHO, 2015). It is progressively effective in the administration of falciparum disease and undiscovered intestinal sickness cases (Leslie et al., 2007). However, it isn't prescribed as a normal medication inferable from its unfriendly impacts, yet essentially to oversee extreme jungle fever or in zones where different medicaments are inadequate. Unfavorable impacts incorporate cerebral p ain, rash, looseness of the bowels, male pattern baldness, stomach cramps, aplastic weakness, atrophic glossitis, fever, hepatic irritation, liver putrefaction, renal poisonousness, photosensitivity, Stevens-Johnson condition, harmful epidermal necrolysis, weight reduction and so on. Indoor remaining showering (IRS) - It is the technique of splashing the inside of a shut office with bug sprays to annihilate mosquitoes that convey intestinal sickness contamination. Bug sprays are showered on the inward dividers with the goal that the mosquitoes can be executed or kept under control which forestalls the transmission of jungle fever contamination (Aregawi et al., 2009). Prior, it was just suggested for regions with irregular disease of intestinal sickness, yet in 2006 it began supporting the utilization of IRS in areas of endemic, and stable jungle fever contamination (van nook Berg , 2009). As indicated by the Cochrane survey, IRS is a fruitful procedure for diminishing jungle fever disease (Pluess et al., 2010). Be that as it may, just a bunch of studies have assessed the practical parts of IRS with some other methods for controlling jungle fever disease (Yukich et al., 2008). However as for the utilization of an assortment of pesticides, DDT has been believed to be the financially savvy, since it keep going for longer time therefore decreasing the recurrence of showering. However, concentrates on cost adequacy and unfriendly impacts of pesticides use on human and condition wellbeing are still less. Another perspective to be considered is that practically 80% of abodes must be showered with pesticides for IRS to be powerful (WHO, 2006) in any case the program wont be a triumph. Individuals are frequently progressively safe towards DDT shower because of its smell or stains on the inward dividers (Mabaso, Sharp Lengeler, 2004; Thurow, 2001). All things considered, pyrethroid bug sprays are increasingly good as they dont leave any noticeable deposits. Malathion splashing in the North West Frontier Province in Pakistan gave defensive viability of 52.5% against falciparum contamination while 40.5% against vivax disease. The vector (Anopheles stephensi) is distinguished as impervious to malathion in the district, and changing from malathion to ano ther bug spray, lambda-cyhalothrin for showering expanded the insurance adequacy. On the other hand, a steady malathion showering drive diminished the recurrence of intestinal sickness contamination, when utilized alongside ITNs by practically 90% in Pakistan. It was evaluated that the showering plans would be affordable than the utilization of ITNs (Rowland et al., 1997a; Rowland et al., 1997b; Rowland, 1999). Bug spray rewarded nets (ITNs) Mosquito bed-nets which are recently rewarded with bug sprays (ITNs) were first made for jungle fever anticipation during the 1980s. They are attempted to be twice as productive as normal bed-nets, and practically 70% more successful than having no net (Bachou et al., 2006). These nets are plunged in a pyrethroid bug spray (permethrin or) which helps in slaughtering or repulsing the mosquitoes. For greatest effectiveness, ITNs must be dunked in pesticides after like clockwork. Be that as it may, it represents an extensive calculated difficulty in country parts. In this way, presently most recent ITNs with durable bug sprays (Long enduring insecticidal nets [LLINs]) have supplanted the more seasoned forms in numerous countries (Masum et al., 2010). ITNs have been exhibited to be cost-proficient viable in jungle fever counteraction (WHO, 2013). ITNs safeguard individuals who rest under them and simultaneously execute mosquitoes that connect with the nets. It offers some security to oth ers dozing in a similar region however without a net. Yet, considers have additionally proposed that transmission of ailment might be disturbed with the loss of insecticidal property of bed-nets. Likewise, the individuals who are not utilizing ITN close to the net clients may encounter raised nibbles as mosquitoes get redirected from the non deadly ITN clients. This could expand the intestinal sickness transmission in thickly populated regions (Yakob Guiyun, 2009). In the North West Frontier Province, Pakistan, the permethrin-rewarded bed-nets offered a defensive adequacy of 61% against falciparum contamination while 47% against vivax disease (Rowland et al., 1997a; Rowland et al., 1997b; Rowland, 1999). References Aregawi, M., Cibulskis, R.E., Otten, M. what's more, Williams, R., 2009.World jungle fever report 2009. World Health Organization. Bachou, H., Tylleskr, T., Kaddu-Mulindwa, D.H. what's more, Tumwine, J.K., 2006. Bacteraemia among seriously malnourished kids contaminated and uninfected with the human immunodeficiency infection 1 in Kampala, Uganda.BMC irresistible diseases,6(1), p.160. Bobenchik, A.M., Choi, J.Y., Mishra, A., Rujan, I.N., Hao, B., Voelker, D.R., Hoch, J.C. what's more, Mamoun, C.B., 2010. ID of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase utilizing a catalyst coupled transmethylation assay.BMC biochemistry,11(1), p.4. Feed, S.I., Guerra, C.A., Gething, P.W., Patil, A.P., Tatem, A.J., Noor, A.M., Kabaria, C.W., Manh, B.H., Elyazar, I.R., Brooker, S. furthermore, Smith, D.L., 2009. A world intestinal sickness map: Plasmodium falciparum endemicity in 2007.PLoS Med,6(3), p.e1000048. Hempelmann, E., 2007. Hemozoin biocrystallization in Plasmodium falciparum and the antimalarial movement of crystallization inhibitors.Parasitology research,100(4), pp.671-676. Khattak, A.A., Venkatesan, M., Khatoon, L., Ouattara, A., Kenefic, L.J., Nadeem, M.F., Nighat, F., Malik, S.A. furthermore, Plowe, C.V., 2013. Commonness and examples of antifolate and chloroquine medicate obstruction markers in Plasmodium vivax across Pakistan.Malaria journal,12(1), p.310. Leslie, T., Mayan, M.I., Hasan, M.A., Safi, M.H., Klinkenberg, E., Whitty, C.J. furthermore, Rowland, M., 2007. Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax intestinal sickness in Afghanistan and Pakistan: a randomized controlled trial.Jama,297(20), pp.2201-2209. Lin, J.W., Spaccapelo, R., Schwarzer, E., Sajid, M., Annoura, T., Deroost, K., Ravelli, R.B., Aime, E., Capuccini, B., Mommaas-Kienhuis, A.M. furthermore, OToole, T., 2015. Replication of Plasmodium in reticulocytes can happen without hemozoin arrangement, bringing about chloroquine resistance.Journal of Experimental Medicine,212(6), pp.893-903. Mabaso, M.L., Sharp, B. also, Le

Biology High School Essay Example | Topics and Well Written Essays - 500 words

Science High School - Essay Example For instance, a cell in a hypotonic arrangement will grow, while a cell in a hypertonic arrangement will recoil. One factor that ought to be considered in assessing the legitimacy of the information is the way of structuring the investigation. The examination ought to obviously characterize the needy and free factors of the investigation. Furthermore, the examination ought to likewise show that a control was utilized. The examination ought to likewise utilize an investigation populace that is sufficiently enormous to forestall any predisposition. So as to decide if a logical finding is pertinent to my life, the zone of study ought to be related to my present condition. For instance, if the new logical finding depicts the advantages of eating a specific vegetable, at that point this is appropriate to my life since it will assist me with improving my wellbeing. Blunders can be brought into an investigation through inappropriate marking of the test arrangement. Furthermore, blunders can likewise be presented by poor estimations abilities in the investigation. So as to decrease the measure of blunder while directing a test, one ought to appropriately name the exploratory arrangement. It is likewise significant that estimations in the analysis be done in an exact way.

Coping With Borderline Personality Disorder in College

Coping With Borderline Personality Disorder in College BPD Living With BPD Print Coping With Borderline Personality Disorder in College By Erin Johnston, LCSW Erin Johnston, LCSW is a therapist, counselor, coach, and mediator with a private practice in Chicago, Illinois. Learn about our editorial policy Erin Johnston, LCSW Updated on September 18, 2019 FatCamera / Getty Images More in BPD Living With BPD Diagnosis Treatment Related Conditions Living with borderline personality disorder (BPD) affects nearly every area of your life, especially where there are people involved. We also know that having BPD can affect college success. Lets take a look at an example of a person attending college with BPD, and the specific issues that can arise. An Example of How BPD Can Affect College Success A story can be worth thousands of words when it comes to describing how having borderline personality disorder (BPD) can affect the college or university experience. In order to better describe both the experience and issues a person with BPD may face, we will use a case report of a woman whose name has been changed to Martha to protect her privacy. As you read through this example, think about your own life. Have you faced circumstances similar to those faced by Martha? Did you have any of the same reactions? Then read on to learn about how some of the common issues faced by people with BPD may play a role. Background on Borderline Personality Disorder Lets start at the beginning. Having taken the last year off, Martha is planning on returning to college in the fall. Her break came as a result of not participating in classes the previous term. Martha just seemed to quit in the middle of her last semester; she stopped going to class, only turned in some of her assignments and started partying. Threatened with academic probation, she decided to sit out for a year and regroup. This was not the first time that Martha had problems in college. In high school, she was always a capable and focused student. When she started college, her future seemed planned and clear. Always one for a cause, Martha initially planned to start and run a non-profit foundation for teenage girls. Once she started school, however, her plans began to get a bit hazy. Borderline Personality Is Marked by Change When Martha took her break from college, she had already changed her major three times in two years and was thinking of changing again. She had started going out to bars until the early hours of the morning, often drinking in her dorm room before she went out (possibly self-medicating behavior). It was not uncommon for her to wake up not knowing where she was or who she was with. Through all of this, she still managed to participate in classes just enough to keep her head above water. But in her last semester, she just stopped going or doing much of anything. Impulsive Behaviors and BPD The Consequences of BPD Symptoms Martha’s last semester had started with a level of enthusiasm that rivaled her first semester in college. She was finally able to register for a class taught by a noted professor at the university. She would pour all of her efforts into assignments for the class and even stopped going out as much. She felt that she was really connecting with her classmates as well. Martha was devastated when her papers were not singled out as being exceptional. The professor did not seem to see her as a superior student. To Martha, it seemed like the professor did not like her at all. (Think about what Martha did here. Have you ever done something similar in some setting in your life?) When Martha mentioned this to her fellow students, they would assure her that the professor was treating all of the students the same. Their lack of validation was intensely frustrating and felt like an additional rejection. Martha felt alone and angry when she thought of class. (Lack of validation in childhood is considered to be one of the risk factors for borderline personality disorder, and even thoughts that a comment or grade, in this case, is invalidating, can bring to mind too many hurtful thoughts to imagine.) Martha stopped going to this class. Perhaps she thought the lack of her valuable contributions would be missed. Or, maybe she was angry and did not want to be where so was not wanted, or she wanted everyone to know how hurt she was. Soon she stopped going to her other classes as well. (To an outsider, this behavior may appear obviously self- sabotaging, but for someone living with borderline personality disorder, the insult is deep.) Common BPD Symptoms In this example, Martha demonstrates the following borderline personality disorder symptoms: Intense/Unstable Interpersonal Relationships: Martha’s initial feelings toward her professor and classmates are intense and idealized. She feels that she is really connecting with her classmates and clearly idolized her professor. These feelings quickly and suddenly change, permanently altering Martha’s perception of her experience. She begins to see her classmates as invalidating and her professor as picking on her because hes not recognizing her.Splitting: When Martha’s perception changes to one of devaluation, it is a total shift from good to bad. She is unable to recognize that she ever felt differently.Sensitivity to Rejection:  Marthas heightened sensitivity to rejection triggered thoughts that her professor and classmates did not like her. The reality of their feelings is truly unknown and may not have that much bearing on Martha’s experience of them.Impulsive, Self-Damaging Behavior: Martha consumed alcohol excessively and was promiscuous. She would wake up with stran gers and in unfamiliar surroundings. Her alcohol use resulted in her being unable to make safe decisions about those she spent her time with.Identity Disturbance: Marthas sense of who she was and what she wanted to do was fluid. Once she entered college, she lost her sense of self and found focusing on a clear self-directed goal impossible. Coping With Borderline Personality Disorder (BPD) Many people with BPD will see themselves, at least to some degree, in the example described above. The process of reading through this example may even make you feel like you want to go to bat for Martha, as you understand the hurt in her heart that has led to her choices. Find Help With the 9 Best Online Therapy Programs Whats important to understand is that the way this interaction unfolds can be changed. And the change doesnt have to originate from the culprit changing their ways, but rather in you changing how you interpret the events, and in doing so, change the way you respond to what transpired. Looking at examples in your own life can be helpful when they are broken down as Marthas story is here. If youre living with BPD, find a good therapist who can help you work through the issues posed by BPD. How to Find a Therapist for BPD

American history from 1815 to 1840 Essay - 1054 Words

Throughout American history, politics changed with the times, forming and growing as new situations and environments took place. However, the most drastic differences occurred between 1815 and 1840. During this time, the North and South develop different economic systems, which created political differences between the regions. Between 1815 and 1840, the number of eligible voters drastically increased as politicians utilized a wider variety of campaigning methods in order to appeal to as many voters as possible, all essentially caused by economic growth. Politics grow to include universal white male suffrage, a strong national government, and nationalism versus sectionalism. Economic Growth (American System, Industrial Revolution,†¦show more content†¦Political figures began appealing for popular support, using tactics like public rallies, picnics, slanderous charges, and newspapers to capture attention. Document I is a campaign almanac that promotes the 1840 candidacy of H arrison and Tyler. During this time period, it was common for political candidates to use almanacs, tracts, buttons, effigies, and rallies to publicize and romanticize their records. Political parties themselves began to change as people like Martin Van Buren tried to go back to old political parties (Document C). He thought that the best political combination would unite southern planters and â€Å"plain Republicans of the North.† †¨Van Buren was part of a group of shrewd politicians called the Albany Regency--With the help of their newspaper, the Albany Argus, they controlled party nominating conventions and political patronage (spoils system) while in office. The Albany Argus is a great example of how newspapers came to be a big part of politics. Seen in Doc G, the number of different newspapers in the United States increased to 1,200, with the number more than tripling between 1810 and 1835. Newspapers were widely distributed, and—after innovations made newspa pers affordable—were widely used as a campaign tactic. There were many causes of the incredible political changes during 1815-1840’s, but the main cause was economic growth. The War of 1812 caused men like Henry Clay and John Calhoun to findShow MoreRelated Canal Building before 1840 Essay962 Words   |  4 PagesCanal Building before 1840: Essay Throughout history, there has been a need for better mode of transportation in order to keep up with economical growth. Canals have been around since the Ancient Roman Civilizations and still exist today. Canals have been so important because they allow people to travel from one place to another and back by way of water. They require very little energy and maintenance but help trade flow more efficiently. 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Literature Review Essay - 2430 Words

Literature Review The purpose of the study The Purpose of the study was to trace and analyze the impact of sales personnel in the used car industry. The study focuses on the current ways in which used car dealers are marketing their products in the Kingston Metropolitan area. The assessment will be done on the following areas: 1. To what extent do salesperson competence impact on profitability 2. How profitable are salespersons strategies to the company 3. How do salespersons impact on their customer 4. How important are salesperson in the sale of used cars 5. Summary In 1997-98 Jamaica spent US $205.9 million on importing 39292 vehicles. The previous year, US $263.6 million was spent to import 27335 with†¦show more content†¦The first initiative was seminar expositions held to show case their services, with sale representative being present to deal with any quires and initiate a purchase arrangement if the need aroused. The exposition covered four major areas: health and nutrition, care of the skin/hear, plant care floral arranging, as well as creating a more security conscious woman. This effort was aimed directly at marketing Worldtron along with its used cars to the public with special emphasis being placed on women. Sales persons comprise of part of the marketing team, exerting major influence in the design of various advertisement and promotional item thus the increasing extent to which sales person are marketing their product can be seen by the number of pre-owned vehicles being advertised in the Gleaner. Vehicles of all description are placed in a special section of the Gleaner giving the price and other various specifications that the customer might deem necessary. This information is also placed in the Jamaica yellow pages and is assessable via the Internet or the telephone directory. 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Computing Goes Green Free Essays

Gregorio, Marie Grace M. INFOMAN Midterm Exam KTD, Prof. Raymond L. We will write a custom essay sample on Computing Goes Green or any similar topic only for you Order Now Ganotice PART 1: CHAPTER 5- Computing Goes Green 1. What business and social problems does data center power consumption cause? Problems caused by Data Center Power Consumption: BUSINESS PROBLEMSSOCIAL PROBLEMS 1. Electricity consumption doubled1. More servers, more emission of carbon footprints 2. Very high cost for cooling data centers 2. Some materials used are environmentally 3. Heat generated from the servers causes hazardous when not properly disposed equipment failure . What solutions are available for these problems? Which are the most environment-friendly? Solutions that are available for data center problem are: a. Use of Hydroelectric power as a source of electricity b. Replacement of copper wiring to light pulses on microprocessors c. Use of thin computers which are very basic terminal machine that consumes significantly less power than normal computers d. Server Virtualization e. Muticore Processor The most environmental-friendly solutions stated above are virtualizati on and the use of thin computers because both reduce power consumption. Virtualization which creates higher utilization of computer results to fewer data centers therefore electricity consumption is reduced. It is the most efficient means for a cost effective greener computing. On the other hand, the use of thin computers which are directly connected to servers consume significantly less power than normal computers. 3. What are the business benefits and cost of these solutions? Majority of these solutions reduces the consumption of electricity because data servers are utilized to its full capacity therefore operating cost on ata servers are reduced also. As stated in the book, cost reduction ranges from 10% to 25% with the use of new solutions. 4. Should all firms move toward green computing? Why or why not? Yes, all firms should embrace computing green because our mother earth is now very much destroyed with so many pollutants produced daily. Awareness on how we can lessen this is very important and one of this is computing green which in a way can min imize environmental impact and improve power efficiency. How to cite Computing Goes Green, Essay examples

The Mythology Of Ancient Egypt Essays - Religion, Egyptian Gods

The Mythology of Ancient Egypt CREATION Egyptian creation stories tell of several variations of how the world was composed. According to one variation, the ocean was the only thing in existence. Then the sun, Ra, came out of an egg (or a flower in some versions) that appeared on the surface of the water. Ra created four children. They were the gods Shu and Geb and the goddesses Tefnut and Nut. Shu and Tefnut became the air, who stood on Geb, the earth, and held up Nut, who became the sky. Ra ruled over all. It was not uncommon for siblings to have children in ancient Egypt, and Geb and Nut had two sons, Set and Osiris, and two daughters, Isis and Nephthys. Osiris succeeded Ra as the king of the earth, helped by Isis. However, Set hated his brother out of jealousy and killed him. Isis embalmed Osiris' body with the aid of the god Anubis, who then became the god of embalming. Isis then resurrected Osiris, and he became the god of the afterlife and the land of the dead. Horus, the son of Osiris and Isis, later defeated Set in an immense battle and became king of the earth. Another version tells that Ra emerged from primeval waters. From him came Shu, the god of air and Tefnut, the goddess of moisture. From their union came Geb and Nut, who held the same positions as the above version. Yet another version tells that Ra became the god of the afterlife, but was still supreme. GODS The ancient Egyptian theology dealt with hundreds of deities. These gods changed during the different dynasties and their importance depended on the views of the rulers of the kingdom. The Egyptians worshipped their gods at temples, and each was dedicated to a particular god. A statue of the god stood in the center of these temples. Every day, priests would clean and dress the statue and offer it meals before the worshipping ceremonies took place. Ra Ra means "creator." He is or was for a time, in nearly all accounts of Egyptian mythology, the supreme god. He was "the father of the gods, the fashioner of men, the creator of cattle, the lord of all being". He is the god of the sun in most of these accounts and is shown as a man with a falcon's head. He carries a staff and the symbol for life, the ankh. The symbol of the sun, also known as the solar disc, is above his head. Despite the fact that he was a very important figure to Egyptians, he had few temples dedicated to him. This was because of the fact that his importance was reflected in all other worshipping rituals. The pharaohs named themselves as sons of Ra. The passage of the sun across the sky obviously fascinated the Egyptians and from it rose many metaphors. At dawn the sun was regarded as a newborn child emerging from the womb of Nut. The sun was also associated with a falcon flying across the midday sun, thus Ra's appearance. He could also be a boat sailing across the great blue sea of the heavens. At dusk he was an old man stepping down to the land of the dead. Amon Amon is "the complete one". He was regarded as an important deity after the second millennium BC, and considered supreme, surpassing even Ra, after the sixteenth century B.C. He, like most other gods, had the body of a man. He had a human head, and wears a crown with two tall plumes on its top. Amon started out having power over the air or wind, but was not in complete control of these forces. He later acquired powers of fertility that had belonged to the god Min, the god of harvest. By being accepted as the supreme god, Ra was a rival. To satisfy the claims of supremacy made by Amon and Ra, the two deities merged to form the god Amon-Ra or Amon-Re. This new god was worshipped as king of the gods, creator of the universe, and the father of the pharaohs. Amon-Ra was said to have guided the pharaohs in the battlefield. During the battle of Kadesh, 1286 BC, Amon-Ra is supposed to have comforted the pharaoh by saying, "Forward! Your father is with you! My powerful hand will slay a hundred thousand men." Osiris Osiris was said to be the king and judge of the dead. Because the importance of the afterlife was so immense in the Egyptians, Osiris was a very important figure in worship cults.